Transition-Metal-Catalyzed Selective Functionalization of C(sp3 )-H Bonds in Natural Products

Transition-Metal-Catalyzed Selective Functionalization of C(sp<sup>3</sup> )-H Bonds in Natural Products

Angew. Chem. Int. Ed. 201857, 4234-4241.

Direct functionalization of natural products is important for studying structure-activity and structure-property relationships of these molecules. Recent advances in transition-metal-catalyzed functionalizations of C(sp3 )-H bonds, the most abundant yet inert bonds in natural products, have been shown to create natural product derivatives selectively. Strategies to achieve such transformation are reviewed.

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