Combinatorial Catalyst Discovery

Combinatorial Catalyst Discovery

We have been developing alternative approaches to the conventional methods for catalyst discovery and development. In particular, we have used fluorescent and colorimetric assays to evaluate catalysts for carbon-carbon and carbon-nitrogen bond forming processes catalyzed by transition metal complexes. With this approach, we discovered the catalysts for hydroamination of substrates with C=C bonds discussed above and for several types of room temperature cross-coupling reactions. Most recently, we have followed an approach to discover new reactions by adding catalysts to mixture of reagents and analyzing for new products by mass spectrometry. In current studies, we are developing an informatics approach to deciphering the products formed from these systems.